Molecular Formula | C15H20N2O6S |
Molar Mass | 356.39 |
Melting Point | 148-150° |
Solubility | H2O: soluble4.0ML, clear, colorless to faint yellow or tan (Solvent: 200 mg plus 4.0 mL ) |
Storage Condition | Inert atmosphere,Room Temperature |
In vitro study | Pyrantel induces Ascaris suum muscle contraction, with a pEC 50 of 7.24. Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle. Pyrantel (72 h) inhibits the survival of Ancylostoma ceylanicum , Necator americanus and Trichuris muris on the third-stage larvae (IC 50 s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC 50 s=>100, 7.6, and 34.1 µg/mL, respectively). |
In vivo study | Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%. |
Hazard Symbols | T - Toxic |
Risk Codes | 25 - Toxic if swallowed |
Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | UW0249000 |
HS Code | 2934990002 |
Hazard Class | 6.1(b) |
Packing Group | III |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.806 ml | 14.03 ml | 28.059 ml |
5 mM | 0.561 ml | 2.806 ml | 5.612 ml |
10 mM | 0.281 ml | 1.403 ml | 2.806 ml |
5 mM | 0.056 ml | 0.281 ml | 0.561 ml |